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EJNMMI Research
Fig. 2 | EJNMMI Research

Fig. 2

From: Hypoxia and glucose metabolism assessed by FMISO and FDG PET for predicting IDH1 mutation and 1p/19q codeletion status in newly diagnosed malignant gliomas

Fig. 2

a ROC curve of FMISO PET for differentiating IDH1-wildtype tumors from IDH1-mutant tumors in all malignant gliomas (n = 87). The area under the curve (AUC) of the FMISO TBR was 0.777 (95% CI 0.669–0.885). When the cutoff value for the FMISO TBR in the ROC curve was set at 2.22, the sensitivity for the differential diagnosis was 81.0%, and the specificity was 65.2%. b ROC curve of FMISO PET for differentiating IDH1-wildtype tumors from IDH1-mutant tumors in malignant astrocytomas (n = 76; 18 AAs and 58 GBMs). The AUC of the FMISO TBR was 0.758 (95% CI 0.598–0.917). When the cutoff value for the FMISO TBR in the ROC curve was set at 1.968, the sensitivity for the differential diagnosis was 70%, and the specificity was 68.2%

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