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Table 1 Patient characteristics [18F]-FDG-PET/MRI parameters and results of further staging examinations

From: Whole-body [18F]-FDG-PET/MRI for staging of pediatric non-Hodgkin lymphoma: first results from a single-center evaluation

Pat

Age

Histology

ENTclin

TC

LP

BMB

USabdomen

18F-FDGadm

18F-FDGrecom

Δinject/scan

Sedation

Images performed

Result of PET/MR scan

Figure

1

15 years

Burkitt

n.d

n.d

Splenomegaly, otherwise US -

212 MBq

(− 39%)

348 MBq

90 min

No

WB PET;

WB MR T2-TIRMcor + trans;

WB DWItrans

Nodular lymphoma involvement on both sides of the diaphragm

 

2

16 years

DLBCLoss

 + 

276 MBq

(− 24%)

363 MBq

90 min

No

WB PET;

WB MR T2-TIRMcor + trans;

WB DWItrans

Nodular lymphoma involvement on both sides of the diaphragm, extensive involvement of the left pelvic bones with cortical bone destruction and infiltration of adjacent muscles

Figure 8i–l

3

6 years

DLBCL

n.d

64 MBq

(− 49%)

126 MBq

135 min

Yes

WB PET;

WB MR T2-TIRMcor + trans;

WB DWItrans

Nodular lymphoma involvement on both sides of the diaphragm

Figures 1, 3

4

7 years

DLBCL

n.d

91 MBq

(− 39%)

148 MBq

110 min

No

WB PET;

WB MR T2-TIRMcor + trans;

WB DWItrans

Nodular lymphoma involvement on both sides of the diaphragm

 

5

10 years

DLBCLoss

n.d

126 MBq

(− 45%)

229 MBq

180 min

No

WB PET;

WB MR T2-TIRMcor + trans;

WB DWItrans

Long segmental lymphoma involvement of the left femur with cortical bone destruction and infiltration of adjacent muscles

 

6

10 years

T-cell lymphoma

n.d

Bilateral renal involvement,

otherwise US -

278 MBq

(+ 0%)

277 MBq

110 min

No

WB PET;

WB MR T2-TIRMcor + trans;

WB DWItrans

Nodular lymphoma involvement on both sides of the diaphragm including Waldeyer’s ring. In addition bilateral kidney and skeletal involvement (right femur)

Figures 6, 7

7

14 years

Burkitt

n.d

162 MBq

(− 45%)

292 MBq

45 min

No

WB PET;

WB MR T2-TIRMcor + trans;

WB DWItrans

Nodular lymphoma involvement above diaphragm including Waldeyer’s ring. Moreover, focal skeletal involvement

Figures 4, 7, 8a–h

8

15 years

T-cell lymphoma

+

n.d

Bilateral renal involvement,

otherwise US -

67 MBq

(− 67%)

200 MBq

70 min

No

WB PET;

WB MR T2-TIRMcor + trans;

WB DWItrans

Nodular lymphoma involvement above diaphragm including left pleura, extended bilateral and focal skeletal involvement (left femur). Waldeyer’s ring involvement most unlikely

Figure 2

9

4 years

T-cell lymphoma

+

+

45 MBq

(− 51%)

92 MBq

70 min

No

WB PET;

WB MR T2-TIRMcor + trans;

WB DWItrans n.e

Nodular lymphoma involvement above diaphragm and left-sided pleural involvement. Waldyer’s ring involvement most unlikely

Figure 5

10

17 years

DLBCL

n.d

239 MBq

(− 31%)

348 MBq

80 min

No

WB PET;

WB MR T2-TIRMcor + trans

WB DWItrans n. d

Nodular lymphoma involvement above diaphragm

 
  1. BMB, Result of Bone Marrow Biopsy; Cor, coronal; DLBCLoss, Primary Osseous Large B-cell Lymphoma; ENTclin, Result of clinical ENT investigation; 18F-FDGadm, Administered 18F-FDG activity; LP, Result of Lumbar Puncture; min, minutes; n.e., not evaluable; TC, Thoracentesis; Trans, transversal; USabdomen, Result of abdominal ultrasound; y, years; Δinject/scan, Time interval from tracer injection to scan start; + , positive for lymphoma; −, negative for lymphoma; Burkitt, Burkitt Lymphoma; DLBCL, Diffuse Large B-cell Lymphoma; DWI, Diffusion Weighted Imaging; f, female; 18F-FDGrecom, Recommended 18F-FDG activity; m, male; n.d., not done; Pat, Patient number; T-cell LL, T-cell Lymphoma; T2-TIRM, T2 weighted Turbo-Inversion Recovery Magnitude; WB, wholebody