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Fig. 3 | EJNMMI Research

Fig. 3

From: Competitive blocking of salivary gland [18F]DCFPyL uptake via localized, retrograde ductal injection of non-radioactive DCFPyL: a preclinical study

Fig. 3

Experimental design for systemic study (SYS group) and intraglandular blocking study (CAN group) in the validation 22RV1 tumor-bearing cohort (a, b). The tissue/blood ratios of [18F]DCFPyL in submandibular salivary glands (SMG) and the tumor at 1 h post-injection are shown for the SYS group (panels c, d) and for the CAN group (panels e, f), respectively. Mice were injected either with 50 µl of saline control or with “cold” DCFPyL at 0.1 × or 1 × molar equivalent of the systemically injected “hot” [18F]DCFPyL dose. Each value in the graphs represents mean tissue/blood ratios ± SD, n = 5–7 for each group, with statistically significant results (P < 0.05) indicated by asterisk. Mice in the CAN 0.1 × and 1 × groups demonstrate statistically significant local blocking at the SMG with no reduction in [18F]DCFPyL uptake at the tumor

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