Fig. 4
From: In vitro proof of concept studies of radiotoxicity from Auger electron-emitter thallium-201
201Tl radiotoxicity—clonogenic survival. a Clonogenic survival (%) in DU145 (n = 3) and MDA-MD-231 cells (n = 3 except 8000 kBq/mL where n = 1) after 90 min incubation with [201Tl]TlCl in medium. b Clonogenic survival (%) measured in DU145 cells (n = 3) and MDA-MB-231 cells (n = 1) after 90 min incubation in medium with different concentrations of non-radioactive [201Tl]TlCl decayed sample. c Clonogenic survivals (%) versus 201Tl intracellular activity per single cell in DU145 cells (n = 3) and d MDA-MB-231 cells (n = 3). Linear quadratic survival model was fitted and calculated activity causing at least 90% reduction was 0.29 Bq for DU145 cells (95% CI 0.18–0.49) and 0.18 Bq for MDA-MB-231 (95% CI 0.10–0.39). Some error bars are smaller than the data points and not visible. Data are presented as mean ± SD, triplicates