Fig. 1
From: Intraoperative visualization of nerves using a myelin protein-zero specific fluorescent tracer
Myelin protein zero as a target for nerve imaging. A schematic overview of the localization of myelin protein zero (P0) in the peripheral nervous system with (I) the location of the nervus ischiadicus (encircled in grey), (II) myelinated axon within this nerve, (III) the myelin sheath encapsulating the axon, (IV) densely packed myelin within the myelin sheath, (V) homotypic binding of P0 within the myelin sheath (location P0 on outer membrane and between layers annotated in black) and (VI) the crystal structure of the extracellular portion of P0 (P0ex). B Peptides P01–25, P021–45, P041–65, P061–85, P081–105, P095–120 and P0101–125 derived from the crystal structure of P0ex with the specific section of the amino acid sequence included in the peptide highlighted in blue and the location of Cy5 functionalization represented by a red-light bulb