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Table 2 Average kinetic parameters from the two-tissue compartment model

From: A dual-time-window protocol to reduce acquisition time of dynamic tau PET imaging using [18F]MK-6240

Diagnosis Region Mean K1 (SD) Mean k2 (SD) Mean k3 (SD) Mean k4 (SD) Mean DVR (SD) Mean VT (SD)
HC Cerebellum 0.402 (0.07) 0.151 (0.01) 0.0107 (0.002) 0.0160 (0.005) - 4.63 (1.5)
VOI 1 0.273 (0.04) 0.136 (0.01) 0.0173 (0.003) 0.0200 (0.007) 0.85 (0.72) 3.85 (0.9)
VOI 2 0.301 (0.06) 0.124 (0.01) 0.0148 (0.003) 0.0264 (0.006) 0.84 (0.11) 3.80 (0.7)
VOI 3 0.283 (0.04) 0.125 (0.004) 0.0138 (0.002) 0.0189 (0.006) 0.88 (0.10) 4.01 (0.9)
VOI 3+ 0.255 (0.04) 0.124 (0.003) 0.0155 (0.0003) 0.0157 (0.002) 0.91 (0.12) 4.11 (0.7)
VOI 4 0.325 (0.05) 0.140 (0.01) 0.0139 (0.002) 0.0172 (0.005) 0.94 (0.07) 4.30 (1.1)
VOI 5 0.362 (0.05) 0.160 (0.01) 0.0155 (0.002) 0.0198 (0.004) 0.90 (0.08) 4.10 (1.0)
VOI 6 0.345 (0.05) 0.165 (0.01) 0.0168 (0.001) 0.0208 (0.004) 0.84 (0.09) 3.82 (0.9)
MCI/AD Cerebellum 0.408 (0.09) 0.140 (0.01) 0.0198 (0.002) 0.0264 (0.007) - 5.20 (1.0)
VOI 1 0.243 (0.03) 0.102 (0.02) 0.0380 (0.006) 0.0147 (0.004) 1.78 (0.62) 9.31 (4.0)
VOI 2 0.256 (0.04) 0.105 (0.02) 0.0343 (0.007) 0.0203 (0.008) 1.44 (0.57) 7.52 (3.6)
VOI 3 0.240 (0.05) 0.089 (0.02) 0.0363 (0.010) 0.0142 (0.004) 2.02 (0.87) 10.54 (5.3)
VOI 3+ 0.223 (0.05) 0.089 (0.02) 0.0349 (0.007) 0.0157 (0.004) 1.71 (0.64) 8.79 (3.6)
VOI 4 0.292 (0.09) 0.104 (0.03) 0.0353 (0.014) 0.0166 (0.005) 2.08 (1.26) 10.83 (7.0)
VOI 5 0.329 (0.07) 0.140 (0.02) 0.0326 (0.009) 0.0208 (0.008) 1.36 (0.63) 7.09 (3.6)
VOI 6 0.338 (0.06) 0.162 (0.02) 0.0321 (0.008) 0.0230 (0.010) 1.10 (0.51) 5.67 (2.6)