From: A dual-time-window protocol to reduce acquisition time of dynamic tau PET imaging using [18F]MK-6240
Diagnosis | Region | Mean K1 (SD) | Mean k2 (SD) | Mean k3 (SD) | Mean k4 (SD) | Mean DVR (SD) | Mean VT (SD) |
---|---|---|---|---|---|---|---|
HC | Cerebellum | 0.402 (0.07) | 0.151 (0.01) | 0.0107 (0.002) | 0.0160 (0.005) | - | 4.63 (1.5) |
VOI 1 | 0.273 (0.04) | 0.136 (0.01) | 0.0173 (0.003) | 0.0200 (0.007) | 0.85 (0.72) | 3.85 (0.9) | |
VOI 2 | 0.301 (0.06) | 0.124 (0.01) | 0.0148 (0.003) | 0.0264 (0.006) | 0.84 (0.11) | 3.80 (0.7) | |
VOI 3 | 0.283 (0.04) | 0.125 (0.004) | 0.0138 (0.002) | 0.0189 (0.006) | 0.88 (0.10) | 4.01 (0.9) | |
VOI 3+ | 0.255 (0.04) | 0.124 (0.003) | 0.0155 (0.0003) | 0.0157 (0.002) | 0.91 (0.12) | 4.11 (0.7) | |
VOI 4 | 0.325 (0.05) | 0.140 (0.01) | 0.0139 (0.002) | 0.0172 (0.005) | 0.94 (0.07) | 4.30 (1.1) | |
VOI 5 | 0.362 (0.05) | 0.160 (0.01) | 0.0155 (0.002) | 0.0198 (0.004) | 0.90 (0.08) | 4.10 (1.0) | |
VOI 6 | 0.345 (0.05) | 0.165 (0.01) | 0.0168 (0.001) | 0.0208 (0.004) | 0.84 (0.09) | 3.82 (0.9) | |
MCI/AD | Cerebellum | 0.408 (0.09) | 0.140 (0.01) | 0.0198 (0.002) | 0.0264 (0.007) | - | 5.20 (1.0) |
VOI 1 | 0.243 (0.03) | 0.102 (0.02) | 0.0380 (0.006) | 0.0147 (0.004) | 1.78 (0.62) | 9.31 (4.0) | |
VOI 2 | 0.256 (0.04) | 0.105 (0.02) | 0.0343 (0.007) | 0.0203 (0.008) | 1.44 (0.57) | 7.52 (3.6) | |
VOI 3 | 0.240 (0.05) | 0.089 (0.02) | 0.0363 (0.010) | 0.0142 (0.004) | 2.02 (0.87) | 10.54 (5.3) | |
VOI 3+ | 0.223 (0.05) | 0.089 (0.02) | 0.0349 (0.007) | 0.0157 (0.004) | 1.71 (0.64) | 8.79 (3.6) | |
VOI 4 | 0.292 (0.09) | 0.104 (0.03) | 0.0353 (0.014) | 0.0166 (0.005) | 2.08 (1.26) | 10.83 (7.0) | |
VOI 5 | 0.329 (0.07) | 0.140 (0.02) | 0.0326 (0.009) | 0.0208 (0.008) | 1.36 (0.63) | 7.09 (3.6) | |
VOI 6 | 0.338 (0.06) | 0.162 (0.02) | 0.0321 (0.008) | 0.0230 (0.010) | 1.10 (0.51) | 5.67 (2.6) |