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Table 2 [18F]FDG kinetics and cerebral metabolic rates of glucose (CMRglu) of conscious and anesthetized rats

From: Conscious rat PET imaging with soft immobilization for quantitation of brain functions: comprehensive assessment of anesthesia effects on cerebral blood flow and metabolism

  K1 (g/mL/min) k2 (/min) k3 (/min) k4 (/min) CMRglu (mg/100 g/min)
Conscious 0.077 ± 0.015 0.119 ± 0.075 0.203 ± 0.156 0.012 ± 0.010 9.37 ± 1.85
MMB 0.086 ± 0.020 0.181 ± 0.076 0.089 ± 0.043** 0.001 ± 0.001 7.56 ± 0.93*
KX 0.065 ± 0.011 0.107 ± 0.030 0.058 ± 0.009** 0.001 ± 0.002 6.93 ± 0.61*
Chloral 0.105 ± 0.015 0.165 ± 0.052 0.072 ± 0.012* 0.001 ± 0.002 7.41 ± 1.15*
PTB 0.099 ± 0.020 0.151 ± 0.058 0.091 ± 0.036* 0.001 ± 0.001 6.68 ± 1.28**
PF 0.112 ± 0.024 0.219 ± 0.142 0.097 ± 0.060** 0.001 ± 0.001 6.22 ± 1.68**
IFL 0.102 ± 0.006 0.187 ± 0.044 0.062 ± 0.032** 0.001 ± 0.003 5.46 ± 1.69**
  1. Data are expressed as mean ± SD (n = 6–7). *P < 0.05 and **P < 0.01 compared with conscious rats as determined using ANOVA with Dunnett’s multiple comparison test