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Table 3 Test–retest variability and reliability of different parameters of [18F]LSN3316612 binding

From: Region- and voxel-based quantification in human brain of [18F]LSN3316612, a radioligand for O-GlcNAcase

 

Testa

Retesta

TRV (%)

aTRV (%)

ICC

Region level

VT2TCM

13.2 (17.8)

14.7 (20.1)

10.1

11.7

0.70

VTLogan

12.7 (19.0)

14.0 (19.6)

10.1

10.7

0.73

VTMA1

12.2 (17.8)

13.5 (19.7)

10.2

11.2

0.69

VTSA

14.9 (18.3)

16.7 (16.2)

11.5

11.5

0.71

IRF120

0.04 (32.4)

0.04 (25.3)

16.4

20.8

0.71

Voxel level

VTLogan

12.3 (16.4)

13.7 (20.0)

10.1

12.0

0.58

VTMA1

13.0 (20.4)

14.1 (20.5)

8.4

10.5

0.80

VTSA

15.4 (17.2)

17.0 (15.2)

10.2

10.4

0.74

IRF120

0.04 (32.2)

0.04 (24.7)

15.8

19.7

0.71

  1. TRV, test–retest variability; aTRV, absolute test–retest variability; ICC, intraclass correlation coefficient; VT, total distribution volume; 2TCM, two-tissue compartment model; MA1, multilinear analysis-1; SA, standard spectral analysis; IRF120, impulse response function calculated at 120 min
  2. aData are presented as VT (mL∙cm−3) with a coefficient of variation (%) in parentheses