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Table 3 Test–retest variability and reliability of different parameters of [18F]LSN3316612 binding

From: Region- and voxel-based quantification in human brain of [18F]LSN3316612, a radioligand for O-GlcNAcase

  Testa Retesta TRV (%) aTRV (%) ICC
Region level
VT2TCM 13.2 (17.8) 14.7 (20.1) 10.1 11.7 0.70
VTLogan 12.7 (19.0) 14.0 (19.6) 10.1 10.7 0.73
VTMA1 12.2 (17.8) 13.5 (19.7) 10.2 11.2 0.69
VTSA 14.9 (18.3) 16.7 (16.2) 11.5 11.5 0.71
IRF120 0.04 (32.4) 0.04 (25.3) 16.4 20.8 0.71
Voxel level
VTLogan 12.3 (16.4) 13.7 (20.0) 10.1 12.0 0.58
VTMA1 13.0 (20.4) 14.1 (20.5) 8.4 10.5 0.80
VTSA 15.4 (17.2) 17.0 (15.2) 10.2 10.4 0.74
IRF120 0.04 (32.2) 0.04 (24.7) 15.8 19.7 0.71
  1. TRV, test–retest variability; aTRV, absolute test–retest variability; ICC, intraclass correlation coefficient; VT, total distribution volume; 2TCM, two-tissue compartment model; MA1, multilinear analysis-1; SA, standard spectral analysis; IRF120, impulse response function calculated at 120 min
  2. aData are presented as VT (mL∙cm−3) with a coefficient of variation (%) in parentheses