TY - JOUR AU - Lee, Jae-Hoon AU - Veronese, Mattia AU - Liow, Jeih-San AU - Morse, Cheryl L. AU - Montero Santamaria, Jose A. AU - Haskali, Mohammad B. AU - Zoghbi, Sami S. AU - Pike, Victor W. AU - Innis, Robert B. AU - Zanotti-Fregonara, Paolo PY - 2021 DA - 2021/04/01 TI - Region- and voxel-based quantification in human brain of [18F]LSN3316612, a radioligand for O-GlcNAcase JO - EJNMMI Research SP - 35 VL - 11 IS - 1 AB - Previous studies found that the positron emission tomography (PET) radioligand [18F]LSN3316612 accurately quantified O-GlcNAcase in human brain using a two-tissue compartment model (2TCM). This study sought to assess kinetic model(s) as an alternative to 2TCM for quantifying [18F]LSN3316612 binding, particularly in order to generate good-quality parametric images. SN - 2191-219X UR - https://doi.org/10.1186/s13550-021-00780-z DO - 10.1186/s13550-021-00780-z ID - Lee2021 ER -