TY - JOUR AU - Urbak, Laerke AU - Ripa, Rasmus S. AU - Sandholt, Benjamin V. AU - Kjaer, Andreas AU - Sillesen, Henrik AU - Graebe, Martin PY - 2021 DA - 2021/03/23 TI - Carotid plaque inflammatory activity assessed by 2-[18F]FDG-PET imaging decrease after a neurological thromboembolic event JO - EJNMMI Research SP - 30 VL - 11 IS - 1 AB - Atherosclerotic plaque vulnerability is comprised by plaque composition driven by inflammatory activity and these features can be depicted with 3D ultrasound and 2-[18F]FDG-PET, respectively. The study investigated timely changes in carotid artery plaque inflammation and morphology after a thromboembolic event with PET/CT and novel ultrasound volumetric grayscale median (GSM) readings. Patients with a single hemisphere-specific neurological symptom and the presence of an ipsilateral carotid artery atherosclerotic plaque were prospectively included to both 2-[18F]FDG PET/CT and 3D ultrasound scans of the plaque immediately after their event and again three months later. On PET/CT images the maximum standardized uptake value (SUVmax) was measured and the volumetric ultrasound acquisitions were analyzed using a semiautomated software measuring GSM values. SN - 2191-219X UR - https://doi.org/10.1186/s13550-021-00773-y DO - 10.1186/s13550-021-00773-y ID - Urbak2021 ER -