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EJNMMI Research
Fig. 1 | EJNMMI Research

Fig. 1

From: Autoradiographical assessment of inflammation-targeting radioligands for atherosclerosis imaging: potential for plaque phenotype identification

Fig. 1

a % DAB positive area in sections categorized as early plaque, stable plaque (FCALC), and vulnerable plaque. b % Added activity/mm2 (%AA/mm2) per radioligand in different plaque categories. Note that the y-axis consists of two segments. c Representative examples of autoradiograms of the different radioligands and immunohistochemistry of adjacent sections stained for the radioligand target. The autoradiograms are not uniformly scaled, but scaled for visibility per image. DOTATATE, DOTA-JR11, DANBIRT, and EC0800 were labelled with Indium-111, Pentixafor was labelled with Gallium-67. Bars indicate mean with standard deviation. *indicates p < 0.05, **indicates p < 0.01, ***indicates p ≤ 0.001. ARG autoradiography, IHC immunohistochemistry, SST2 somatostatin subtype receptor 2, CXCR4 chemokine CXC motif receptor type 4, LFA-1 leukocyte associated antigen 1, FR folate receptor, FCALC fibro-calcific, DAB 3,3′-Diaminobenzidine

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