Fig. 3:

3D PET/MRI images of the brain obtained 30 min after i.v. administration of [¹⁸F]FEPPA in control and 24 h LPS-injected animals (5 mg/kg, i.p.). Significantly higher [¹⁸F]FEPPA uptake was observed in all brain regions of the LPS group at 24 h compared to the control group. [¹⁸F]FEPPA TSPO binding were more region-specific or globally distributed in the brain. PET images were generated by summation of the whole scan (0–30 min); the mean SUV value of each group is represented and color-coded to the range of SUV values (n = 6–8 mice per group)