Fig. 3
From: Iodine-124 PET quantification of organ-specific delivery and expression of NIS-encoding RNA
Ex vivo quantification of organ iodine uptake. a–f Iodine-124 uptake in organs was measured 9 h after RNA-lipoplex injection (3 h after Iodine-124 injection). Organs were weighed and % ID calculated from counts on a cross-calibrated gamma counter. a Radioactive uptake as a result of anionic RNA-lipoplexes targeting the spleen. b, c Biodistribution of radioactivity as a result of anionic (spleen-targeting) RNA-lipoplexes carrying NIS-RNA (b) or non-coding RNA (c). d Radioactive uptake as a result of cationic RNA-lipoplexes targeting the lung. e, f Biodistribution of radioactivity as a result of cationic (lung-targeting) RNA-lipoplexes carrying NIS-RNA (e) or non-coding RNA (f). Data are shown as mean + SD of n = 3. SG salivary gland, ing LN inguinal lymph node