Fig. 2
From: Increased [18F]FMISO accumulation under hypoxia by multidrug-resistant protein 1 inhibitors
[18F]FMISO-PET imaging of FaDu tumor-xenografted mice pretreated with MRP1 inhibitors [cyclosporine A (CyA), lapatinib, or MK-571]. a Representative [18F]FMISO-PET/CT images of FaDu tumor-xenografted mice. The PET/CT images (1st PET scan) were acquired from FaDu tumor-xenografted mice at 4 h after i.v. administration of [18F]FMISO. Two days after the 1st PET scan, the mice were pretreated with CyA, lapatinib, MK-571, or 5%Tween80 (control), and then, the PET/CT images of [18F]FMISO (2nd PET scan) were acquired from the same mice in the 1st PET scan. The yellow circle indicates tumor tissues. b SUVmean ratio of FaDu tumor tissues acquired from the PET images. The SUVmean ratio was calculated as after treatment (2nd PET scan)/before treatment (1st PET scan). *p < 0.05