Table 1 Nanobodies for molecular imaging

HER1

8B6 (monovalent)

^99mTc

5.2 ± 0.5 %IA/cm³ (3 h)

[26]

7C12 (monovalent)

^99mTc

4.55 ± 0.24 %IA/cm³ (1 h)

[26, 27]

7D12 (monovalent, bivalent)

^99mTc

4.62 ± 0.36 %IA/cm³ (1 h and 3 h)

[26, 27]

OA-cb6 (monovalent)

^99mTc

2.93 ± 0.46 %ID/g (4 h)

[28, 29]

HER2

2Rs15d (monovalent)

^99mTc, ⁶⁸Ga, ¹⁸F

4.23 ± 0.99 %IA/g (1 h)

[23, 32]

11A4 (with IRDye 800CW)

IRDye 800CW

1.8 ± 0.5 %ID/g (1 h)

[33]

5F7GGC (monovalent)

¹³¹I, ¹⁸F

24.50 ± 9.89 %ID/g (8 h, 1 h)

[84]

HER3

MSB0010853 (monovalent)

⁸⁹Zr

6.2 ± 1.1 %ID/g (24 h)

[34]

HGF

1E2 and 6E10 (fused to albumin)

⁸⁹Zr

8.9% ± 1.0 %ID/g (unknown)

[35]

CEA

NbCEA5 (with humanized nanobody scaffold)

^99mTc

7.09 ± 1.36 %IA/cm3 (1 h)

[36]

MMR

α-MMR Nb (monovalent)

^99mTc

3.02 ± 0.10 %IA/g (3 h)

[52]

MMR 3.49 (monovalent)

^99mTc, ⁶⁸Ga, ¹⁸F

2.40 ± 0.46 %IA/g (1 h)

[42,43,44]

VCAM1

cAbVCAM1-5 (monovalent)

^99mTc, ⁶⁴Cu, ¹⁸F

2.99 ± 0.07 %ID/g (2 h)

[45, 46]

VSIG4

NbV4m119 (monovalent)

^99mTc

0.01–0.08 %IA/g (1 h and 3 h)

[64, 65]

PD-L1

Nb109 (monovalent)

⁶⁸Ga

4.94 ± 0.46 %ID/g (1 h)

[69]

CAIX

B9 (with IRDye 800CW)

IRDye 800CW

4.6 ± 0.8 %ID/g (2 h)

[41, 73]