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Table 4 Effectiveness of PET parameters in differentiating the early chemoradiotherapeutic response in patients with head and neck squamous cell carcinoma by receiver operating characteristics (ROC) analysis

From: Interim 4′-[methyl-11C]-thiothymidine PET for predicting the chemoradiotherapeutic response in head and neck squamous cell carcinoma: comparison with [18F]FDG PET

PET parameter AUC (95% CI) Cutoff value Sensitivity Specificity P value
[11C]4DST      
 ΔSUVmax 0.75 (0.52–0.98) − 46 0.57 0.96 0.044
 ΔPTV 0.91 (0.81–1.00) − 90 0.85 0.84 < 0.001
 ΔTLP 0.89 (0.77–1.00) − 99 1.00 0.76 0.002
[18F]FDG      
 ΔSUVmax 0.52 (0.23–0.80) − 51 0.57 0.72 0.874
 ΔMTV 0.33 (0.08–0.59) 7 0.28 0.72 0.194
 ΔTLG 0.32 (0.08–0.57) − 62 0.42 0.48 0.165
  1. SUVmax, maximum standardized uptake value; PTV, proliferative tumor volume; MTV, metabolic tumor volume; TLP, total lesion proliferation; TLG, total lesion glycolysis; AUC, area under the ROC curve; CI, confidence interval