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EJNMMI Research

Table 4 Effectiveness of PET parameters in differentiating the early chemoradiotherapeutic response in patients with head and neck squamous cell carcinoma by receiver operating characteristics (ROC) analysis

From: Interim 4′-[methyl-11C]-thiothymidine PET for predicting the chemoradiotherapeutic response in head and neck squamous cell carcinoma: comparison with [18F]FDG PET

PET parameter

AUC (95% CI)

Cutoff value

Sensitivity

Specificity

P value

[11C]4DST

     

 ΔSUVmax

0.75 (0.52–0.98)

− 46

0.57

0.96

0.044

 ΔPTV

0.91 (0.81–1.00)

− 90

0.85

0.84

< 0.001

 ΔTLP

0.89 (0.77–1.00)

− 99

1.00

0.76

0.002

[18F]FDG

     

 ΔSUVmax

0.52 (0.23–0.80)

− 51

0.57

0.72

0.874

 ΔMTV

0.33 (0.08–0.59)

7

0.28

0.72

0.194

 ΔTLG

0.32 (0.08–0.57)

− 62

0.42

0.48

0.165

  1. SUVmax, maximum standardized uptake value; PTV, proliferative tumor volume; MTV, metabolic tumor volume; TLP, total lesion proliferation; TLG, total lesion glycolysis; AUC, area under the ROC curve; CI, confidence interval
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