PET quantification of brain O-GlcNAcase with [18F]LSN3316612 in healthy human volunteers

EJNMMI Research

Table 3 Variability and reliability of test-retest parameters from 10 healthy volunteers after injection of [¹⁸F]LSN3316612

Parameter^a	Source	Test^b	Retest^b	TRV (%)	aTRV (%)	ICC
V_T	Brain and plasma	13.7 (19.2)	15.3 (19.6)	11.3	12.5	0.64
AUC_150–180	Brain	102.2 (16.3)	103.6 (11.9)	1.8	9.0	0.68
AUC/C_P150–180	Brain and plasma	654.1 (46.2)	661.1 (19.7)	6.5	31.9	0.18
Plasma parent AUC_0–∞	Plasma	105.9 (20.3)	96.0 (20.3)	− 9.7	12.3	0.69
Brain AUC_0–∞	Brain	1428.2 (23.3)	1445.5 (20.6)	1.6	13.3	0.78

TRV test-retest variability, aTRV absolute test-retest variability, ICC intraclass correlation coefficient, V_T total distribution volume, AUC area under the curve, TAC time-activity curve
^aThe measured parameters were V_T total distribution volume (mL·cm⁻³); AUC_150–180 area under the curve of brain TAC of 150–180 min; AUC/C_P150–180 normalized AUC_150–180 to mean parent radioactivity concentration in arterial plasma; AUC_0–∞ area under the curve estimated from 0 min to infinity
^bData are presented as mean with coefficient of variation (%) in parentheses