EJNMMI Research

Table 2 Total distribution volume (V_T) of brain regions after injection of [¹⁸F]LSN3316612

From: PET quantification of brain O-GlcNAcase with [¹⁸F]LSN3316612 in healthy human volunteers

Region	V_T (mL·cm⁻³)^a
Region	Mean	COV (%)
Amygdala	17.6	28.3
Hippocampus	15.5	24.6
Cingulate	14.5	25.2
Insula	14.4	24.0
Temporal	13.9	24.2
Frontal	12.9	23.8
Striatum	12.7	23.7
Parietal	12.2	22.2
Occipital	11.6	21.6
Globus pallidus	11.5	25.0
Cerebellum	11.3	22.3
Thalamus	11.2	22.8
White matter (WM)	10.3	26.2
Cerebellar WM	9.1	23.7
Corpus callosum	8.0	36.8
Brainstem	7.9	24.5
Mean	12.2	24.9

COV coefficient of variation
^aV_T was calculated using a two-tissue compartment model. Values represent the mean and coefficient of variation (COV = mean/SD) from the baseline scans of 17 healthy volunteers

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