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EJNMMI Research
Fig. 2 | EJNMMI Research

Fig. 2

From: Enhancing the therapeutic effects of in vitro targeted radionuclide therapy of 3D multicellular tumor spheroids using the novel stapled MDM2/X-p53 antagonist PM2

Fig. 2

a Dose-response of AbN44v6 on UM-SCC-74B spheroids treated with AbN44v6 (untreated controls, 10 nM, 100 nM, 1 μM) presented as growth ratios over time as well as b representative images of treated spheroids, n ≥ 4, error bars presented as 95% confidence intervals. c Relative pErk1/2 induction following FGF2 stimulation compared to control of HCT116 samples. d Relative pErk1/2 induction following FGF2 stimulation compared to control of UM-SCC-74B samples, n = 3, error bars presented as SD. e Growth inhibitory effects of PM2 measured in spheroid volume (mm3) using two different treatment regimens on HCT116 spheroids and f UM-SCC-74B spheroids. n ≥ 5, error bars presented as 95% confidence intervals

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