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Table 2 Affinity values of NPY-conjugates to the hY1R

From: Design, synthesis, and biological evaluation of a multifunctional neuropeptide-Y conjugate for selective nuclear delivery of radiolanthanides

Compounds

KD at the hY1R (nM)

[F7,P34]-NPY

0.94 ± 0.08

pb12

3.1 ± 0.8

[111In]In-pb12

5.1 ± 3.5

[natTb]Tb-pb12

30 ± 3.7

pb13

No specific binding

[111In]In-pb13

No specific binding

[natTb]Tb-pb13

No specific binding