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Fig. 1 | EJNMMI Research

Fig. 1

From: Design, synthesis, and biological evaluation of a multifunctional neuropeptide-Y conjugate for selective nuclear delivery of radiolanthanides

Fig. 1

Synthesis scheme for the hY1R-targeted, multifunctional NPY conjugate pb12. Dde, 4,4-dimethyl-2,6-dioxocyclohex-1-ylidenethyl; SPPS, solid phase peptide synthesis; Fmoc, 9-fluorenylmethoxycarbonyl; DMF, dimethylformamide; HOBt, 1-hydroxybenzotriazole; DIC, N,N'-diisopropylcarbodiimide; NLS, nuclear localization sequence; DOTA, 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid; TFA, trifluoroacetic acid; TA, thioanisole; TC, thiocresole; Palm, palmitic acid. The cathepsin B-cleavable linker is marked in red and the nuclear localization sequence in blue. a Dde cleavage, b coupling, c Fmoc cleavage, d extension with β-Ala NLS GLFG sequence, e DOTA coupling, f palm coupling, g full cleavage

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