Fig. 4

Safety studies of IR783-AMBF₃. a Effect of IR783-AMBF₃ on murine gliosarcoma (9 L/lacZ), murine endothelioma (bEnd.3) and human microvascular endothelial (HMEC-1) cell viability. Cells were treated with different concentrations of IR-783 (black line) or IR783-AMBF₃ (red line) for 24 h. b Relative mean weight of rats after intrathecal injection of IR783-AMBF₃ at 150 μM (n = 4). Error bars are ± SD. c Biodistribution data collected in different tissues shows that intrathecally injected IR783-AMBF₃ clears from the CSF and blood quickly and is ultimately excreted and through the renal and hepatic systems (n = 3). Error bars are ± SEM