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Fig. 5 | EJNMMI Research

Fig. 5

From: Targeted alpha therapy with astatine-211-labeled anti-PSCA A11 minibody shows antitumor efficacy in prostate cancer xenografts and bone microtumors

Fig. 5

Effect of alpha-RIT with 211At-A11 on intratibial PC3-PSCA microtumors. Treatment was given twice two weeks apart. (a) Individual tumor sizes after treatment with 211At-A11 in study 1. Lines represent the mean size of identified tumors. *p < 0.05 Mann-Whitney U test. (b) Individual tumor sizes after treatment with 211At-A11 in study 2. ***p < 0.001 Mann-Whitney U test. Indicated is also the TFF for each group. (c and d) H&E staining of PC3-PSCA intratibial microtumors growing in the bone marrow and into the cortical bone at treatment start (7 days after cell implantation). Untreated tumor at end of experiment (e), and treated tumor (2 × 0.8 MBq) at end of experiment (f). Cortical bone (cb), bone marrow (bm), tumor (tu). Magnification 200×, black scale bar: 100 μm (c and d), magnification 40×, scale bar: 500 μm (e and f)

TFF tumor free fraction

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