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Table 2 Biodistribution of [99mTc]Tc(CO)3-G3 in NMRI mice 4 h p.i. alone (control) or after administration of compounds

From: On the prevention of kidney uptake of radiolabeled DARPins

 BloodSalivary glandsLiverSpleenGI tractCarcass
Control0.33 ± 0.040.7 ± 0.23.3 ± 0.30.8 ± 0.24 ± 19 ± 1
Lysine0.28 ± 0.030.6 ± 0.13.0 ± 0.20.6 ± 0.14 ± 17 ± 1
Gelofusine0.29 ± 0.040.7 ± 0.22.9 ± 0.40.6 ± 0.13.4 ± 0.28 ± 1
Mannitol0.31 ± 0.040.8 ± 0.23.6 ± 0.30.8 ± 0.13.9 ± 0.39.4 ± 0.4
Furosemide0.33 ± 0.020.9 ± 0.13.3 ± 0.30.8 ± 0.14 ± 110.1 ± 0.3
Probenecid0.32 ± 0.060.7 ± 0.13.2 ± 0.20.9 ± 0.14 ± 18 ± 1
Colchicine0.44 ± 0.04*0.5 ± 0.11.9 ± 0.3*1.2 ± 0.2*2.5 ± 0.4*6.9 ± 0.3
Fructose0.8 ± 0.1*1.9 ± 0.4*7.0 ± 1.0*1.9 ± 0.1*7 ± 1*20 ± 2*
Maleate0.33 ± 0.050.6 ± 0.13.0 ± 0.50.7 ± 0.23.4 ± 0.29 ± 1
  1. Data are presented as average from four mice ± SD, for the control—as average from eight mice ± SD. Uptake is shown in %ID/g, except for GI tract and carcass, which is shown in %ID per whole sample. An asterisk marks a significant difference between the control and the treated group (*p < 0.01, one-way ANOVA test)