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Table 2 Biodistribution of [99mTc]Tc(CO)3-G3 in NMRI mice 4 h p.i. alone (control) or after administration of compounds

From: On the prevention of kidney uptake of radiolabeled DARPins

 

Blood

Salivary glands

Liver

Spleen

GI tract

Carcass

Control

0.33 ± 0.04

0.7 ± 0.2

3.3 ± 0.3

0.8 ± 0.2

4 ± 1

9 ± 1

Lysine

0.28 ± 0.03

0.6 ± 0.1

3.0 ± 0.2

0.6 ± 0.1

4 ± 1

7 ± 1

Gelofusine

0.29 ± 0.04

0.7 ± 0.2

2.9 ± 0.4

0.6 ± 0.1

3.4 ± 0.2

8 ± 1

Mannitol

0.31 ± 0.04

0.8 ± 0.2

3.6 ± 0.3

0.8 ± 0.1

3.9 ± 0.3

9.4 ± 0.4

Furosemide

0.33 ± 0.02

0.9 ± 0.1

3.3 ± 0.3

0.8 ± 0.1

4 ± 1

10.1 ± 0.3

Probenecid

0.32 ± 0.06

0.7 ± 0.1

3.2 ± 0.2

0.9 ± 0.1

4 ± 1

8 ± 1

Colchicine

0.44 ± 0.04*

0.5 ± 0.1

1.9 ± 0.3*

1.2 ± 0.2*

2.5 ± 0.4*

6.9 ± 0.3

Fructose

0.8 ± 0.1*

1.9 ± 0.4*

7.0 ± 1.0*

1.9 ± 0.1*

7 ± 1*

20 ± 2*

Maleate

0.33 ± 0.05

0.6 ± 0.1

3.0 ± 0.5

0.7 ± 0.2

3.4 ± 0.2

9 ± 1

  1. Data are presented as average from four mice ± SD, for the control—as average from eight mice ± SD. Uptake is shown in %ID/g, except for GI tract and carcass, which is shown in %ID per whole sample. An asterisk marks a significant difference between the control and the treated group (*p < 0.01, one-way ANOVA test)