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Fig. 2 | EJNMMI Research

Fig. 2

From: Indium-111-labeled CD166-targeted peptide as a potential nuclear imaging agent for detecting colorectal cancer stem-like cells in a xenograft mouse model

Fig. 2

Identification of cancer stem cell feature in CD166+HCT15 cells. a Morphological characteristics during the growth of tumor spheres for 14 days. The quantitation of cell sphere formation was detected by manual calculation under light microscopy. Magnification, × 400; scale bar, 50 μm. b Colony formation of CD166+HCT15 and CD166HCT15 cells. The representative image was shown and the colony number was quantified. c Cell migration assay. A wound was made in the monolayer in both CD166+HCT15 and CD166HCT15 cells (T0), and then the cells were allowed to migrate for 24 h (T24). The quantification of wound closure was determined by ImageJ software. Magnification, ×100; scale bar, 200 μm. In ac, data are presented as mean ± SD (n = 3).*P < 0.05, versus CD166 group

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