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Table 1 Kinetic parameters estimated by the irreversible two-tissue-compartment model

From: Kinetic modeling of 68Ga-PSMA-11 and validation of simplified methods for quantification in primary prostate cancer patients

 LesionProstateMusclep valueap valueb
K1 (mL/min/mL)0.136 [0.099, 0.229]0.088 [0.078, 0.107]0.028 [0.021, 0.033]0.0060.001
k2 (/mL)0.277 [0.213, 0.484]0.239 [0.147, 0.329]0.285 [0.184, 0.466]0.3080.839
k3 (/mL)0.108 [0.057, 0.125]0.040 [0.036, 0.056]0.040 [0.031, 0.045]0.0050.007
Ki (/mL)0.036 [0.024, 0.076]0.014 [0.010, 0.020]0.003 [0.003, 0.003]0.0010.001
Patlak Ki (/mL)0.035 [0.024, 0.096]0.012 [0.008, 0.022]0.003 [0.003, 0.003]0.0010.001
  1. Median values with interquartile range [Q1, Q3], n = 14 subjects, 18 lesions (median of k2 and k3 from 14 lesions). p values assessed by Wilcoxon test (the most avid lesion per subject selected) comparing lesion with prostate (a) and muscle (b). Ki is the net influx rate calculated from rate constants K1k3/(k2 + k3) or from the slope of the graphical Patlak analysis