Skip to main content

Table 1 Numbers of subjects in each dose group and PET scan time points after oral dosing with the α2C-adrenoceptor antagonist ORM-12741

From: Application of the PET ligand [11C]ORM-13070 to examine receptor occupancy by the α2C-adrenoceptor antagonist ORM-12741: translational validation of target engagement in rat and human brain

Dose (mg) No. of subjects scanned at baseline No. of subjects scanned at 1 h No. of subjects scanned at 3.5 h No. of subjects scanned at 6 h No. of subjects scanned at 6.5 h No. of subjects scanned at 12 h
0.3 2 1 1 1   1
1 3a 1 1 1   1
10 5 3 3 2   2
30 5 3 3 2   2
60 4 4 4   4  
  1. aOne subject discontinued after the baseline scan