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EJNMMI Research
Fig. 1 | EJNMMI Research

Fig. 1

From: Application of the PET ligand [11C]ORM-13070 to examine receptor occupancy by the α2C-adrenoceptor antagonist ORM-12741: translational validation of target engagement in rat and human brain

Fig. 1

a Representative 40 µm coronal brain sections from rats pre-treated with vehicle or ORM-12741 (2, 10, 50 µg/kg subcutaneously) at 10 min post [11C]ORM-13070 intravenous injection. Sections are from the level of the caudate-putamen, olfactory tubercle and frontal cortex. The colour pseudo-autoradiograms show the regional distribution of the [11C]-label, red highest, blue lowest uptake. b The relationship between ORM-12741 (10–1000 µg/kg s.c.) plasma levels and α2C-adrenoceptor occupancy in rat striatum. The blue line represents a binding hyperbole derived from nonlinear regression analysis with a sigmoidal maximum possible effect model. The red lines represent 95% confidence intervals

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