[18F]-Fluciclovine PET discrimination of recurrent intracranial metastatic disease from radiation necrosis

EJNMMI Research

Table 2 SUVmax values for recurrent disease, radiation necrosis, and normal brain

	Recurrent disease (N = 11)	Tumor necrosis (N = 4)	Background (N = 15)	p value
5 m Lesion				0.004
Mean (SD)	1.9 (0.6)	0.8 (0.1)	0.6 (0.2)
Median (range)	2.0 (1.1, 3.1)	0.8 (0.7, 1.0)	0.6 (0.4, 0.9)
5 min TBR_max				0.121
Mean (SD)	3.0 (1.3)	1.8 (0.2)
Median (range)	2.6 (1.3, 5.3)	1.8 (1.6, 2.2)
10 min Lesion				0.033
Mean (SD)	2.3 (1.2)	0.9 (0.2)	0.6 (0.2)
Median (range)	2.0 (1.4, 5.4)	0.9 (0.7, 1.0)	0.6 (0.4, 1.0)
10 min TBR_max				0.129
Mean (SD)	3.4 (1.8)	1.9 (0.5)
Median (range)	3.1 (1.5, 7.8)	1.8 (1.5, 2.6)
30 min Lesion				0.042
Mean (SD)	2.3 (1.1)	1.1 (0.2)	2.0 (1.1)
Median (range)	2.2 (1.4, 5.3)	1.1 (0.8, 1.3)	1.9 (0.8, 5.3)
30 min TBR_max				0.178
Mean (SD)	3.6 (1.9)	2.2 (0.6)
Median (range)	3.2 (1.4, 7.7)	2.3 (1.5, 2.8)
55 min Lesion				0.025
Mean (SD)	2.3 (0.9)	1.1 (0.3)	0.7 (0.2)
Median (range)	2.3 (1.3, 4.4)	1.1 (0.8, 1.4)	0.6 (0.2, 1.2)
55 min TBR_max				0.304
Mean (SD)	3.3 (1.5)	2.5 (0.9)
Median (range)	3.2 (1.4, 5.7)	2.5 (1.4, 3.5)

^*P value for each time point between mean SUVmax of malignant metastatic lesion and radiation necrosis