Clinical implementation of PLANET® Dose for dosimetric assessment after [177Lu]Lu-DOTA-TATE: comparison with Dosimetry Toolkit® and OLINDA/EXM® V1.0

EJNMMI Research

Table 5 Comparison of the AD values to each OAR: liver (a), kidneys (b) and spleen (c) calculated with Dosimetry Toolkit + OLINDA and PLANET® Dose with density correction. DTK, Dosimetry Toolkit

(a)
Dosimetry analyses	Absorbed dose to liver (Gy)
	DTK + OLINDA/EXM® V1.0	PLANET®Dose LDM	PLANET®Dose DK	Relative difference (%)/DTK + OLINDA
	DTK + OLINDA/EXM® V1.0	PLANET®Dose LDM	PLANET®Dose DK	PLANET®Dose LDM	PLANET®Dose DK
1	1.04	1.04	1.02	− 0.1	− 1.9
2	1.59	1.64	1.61	3.2	1.2
3	0.92	0.86	0.85	− 6.7	− 8.3
4	16.44	15.89	15.56	− 3.4	− 5.4
5	14.19	13.31	13.06	− 6.2	− 8.0
6	3.27	3.30	3.24	0.9	− 1.0
7	4.59	4.40	4.32	− 4.1	− 5.9
8	0.57	0.61	0.60	7.0	4.4
9	2.05	2.04	2.00	− 0.3	− 2.2
10	1.26	1.09	1.07	− 13.2	− 14.7
11	1.12	1.11	1.10	− 0.9	− 2.2
12	2.40	2.28	2.23	− 5.0	− 7.0
13	4.02	3.83	3.76	− 4.7	− 6.4
14	0.91	0.93	0.92	2.1	0.7
15	0.79	0.80	0.78	1.3	− 1.0
16	9.58	9.00	8.83	− 6.0	− 7.8
17	9.32	8.88	8.72	− 4.7	− 6.4
18	1.47	1.49	1.44	1.5	− 1.9
19	1.92	1.89	1.86	− 1.8	− 3.3
20	0.94	0.86	0.84	− 8.7	− 10.7
21	1.13	1.18	1.16	4.1	2.4
22	1.65	1.68	1.65	1.8	0.1
23	0.88	0.93	0.91	5.7	3.5
24	6.95	6.89	6.75	− 0.9	− 2.8
25	2.09	2.10	2.06	0.7	− 1.1
26	2.34	2.29	2.25	− 2.1	− 3.8
27	7.57	6.82	6.69	− 9.9	− 11.7
28	0.62	0.65	0.63	5.2	2.7
29	1.61	1.64	1.61	1.9	0.1
30	1.14	1.14	1.12	− 0.4	− 2.3
31	1.39	1.31	1.29	− 5.6	− 7.0
32	2.24	2.19	2.15	− 2.1	− 4.1
33	4.13	4.72	4.25	14.3	2.9
34	0.78	0.84	0.83	7.7	6.5
35	0.81	0.81	0.80	0.0	− 1.6
36	10.43	9.19	9.02	− 11.9	− 13.5
37	8.15	7.51	7.38	− 7.9	− 9.5
38	1.42	1.36	1.34	− 4.1	− 5.7
39	1.57	1.49	1.46	− 5.1	− 6.8
40	0.92	0.94	0.93	2.0	0.5
Mean	3.40	3.27	3.20	− 1.4	− 3.5
SD	3.89	3.65	3.58	5.5	4.9
Min	0.57	0.61	0.60	− 13.2	− 14.7
Max	16.44	15.89	15.56	14.3	6.5
RMSD				5.6	6.0

(b)
Dosimetry analyses	Absorbed dose to kidneys
	DTK + OLINDA/EXM® V1.0	PLANET®Dose LDM	PLANET®Dose DK	Relative difference (%)/DTK + OLINDA
	DTK + OLINDA/EXM® V1.0	PLANET®Dose LDM	PLANET®Dose DK	PLANET®Dose LDM	PLANET®Dose DK
1	2.78	3.14	3.07	12.8	10.3
2	2.79	3.10	3.03	11.1	8.5
3	3.26	3.41	3.33	4.6	2.1
4	3.68	3.45	3.38	− 6.3	− 8.2
5	2.05	2.03	1.91	− 0.7	− 6.9
6	3.06	3.66	3.57	19.6	16.8
7	3.56	3.84	3.75	7.7	5.1
8	3.48	3.83	3.70	10.0	6.2
9	2.53	2.40	2.35	− 5.2	− 7.2
10	3.07	3.29	3.22	7.2	5.0
11	2.10	2.40	2.34	14.3	11.5
12	2.51	2.61	2.56	3.9	1.8
13	3.24	3.35	3.28	3.4	1.1
14	2.44	2.72	2.66	11.5	8.8
15	2.20	2.50	2.45	13.6	11.1
16	1.98	2.10	2.06	5.8	3.8
17	2.96	3.49	3.41	18.0	15.4
18	2.90	3.13	3.05	8.1	5.4
19	4.69	5.37	5.24	14.5	11.7
20	2.48	2.46	2.40	− 0.8	− 3.2
21	3.31	3.73	3.65	12.7	10.2
22	2.85	3.15	3.12	10.7	9.5
23	3.93	4.00	3.91	1.8	− 0.5
24	2.60	2.60	2.54	0.0	− 2.3
25	3.54	3.91	3.82	10.5	8.0
26	3.31	3.50	3.42	5.7	3.3
27	7.36	7.09	6.93	− 3.7	− 5.8
28	3.35	3.86	3.76	15.2	12.3
29	2.51	2.55	2.49	1.6	− 0.8
30	3.32	3.34	3.27	0.6	− 1.6
31	2.62	2.82	2.75	7.5	5.0
32	2.31	2.55	2.49	10.5	8.0
33	3.37	3.92	3.83	16.3	13.5
34	2.53	2.68	2.62	5.9	3.5
35	2.30	2.71	2.64	17.8	14.9
36	2.15	2.22	2.17	3.4	1.2
37	2.08	2.10	2.06	1.2	− 0.8
38	2.87	3.11	3.04	8.5	6.0
39	4.57	5.02	4.90	9.8	7.2
40	2.52	2.80	2.73	11.1	4.6
Mean	3.03	3.25	3.17	7.5	4.9
SD	0.95	0.97	0.95	6.5	6.4
Min	1.98	2.03	1.91	− 6.3	− 8.2
Max	7.36	7.09	6.93	19.6	16.8
RMSD				9.9	8.0

(c)
Dosimetry analyses	Absorbed dose to spleen
	DTK + OLINDA/EXM® V1.0	PLANET®Dose LDM	PLANET®Dose DK	Relative difference (%)/DTK + OLINDA
	DTK + OLINDA/EXM® V1.0	PLANET®Dose LDM	PLANET®Dose DK	PLANET®Dose LDM	PLANET®Dose DK
1	3.86	4.12	4.03	6.8	4.5
2	4.67	5.41	5.28	15.8	13.1
3	3.83	4.40	4.31	15.0	12.5
4	4.01	3.68	3.59	− 8.2	− 10.4
5	4.35	3.93	3.83	− 9.7	− 12.0
6	2.98	3.30	3.23	10.9	8.3
7	5.03	5.37	5.28	6.7	5.0
8	2.07	2.36	2.31	14.3	11.7
9	3.67	3.40	3.32	− 7.2	− 9.4
10	4.87	4.59	4.37	− 5.7	− 10.2
11	3.69	3.83	3.74	3.8	1.4
12	4.27	4.35	4.25	1.8	− 0.5
13	4.17	4.47	4.37	7.2	4.7
14	3.22	3.30	3.22	2.5	0.0
15	2.91	3.33	3.26	14.6	12.0
16	2.94	3.11	3.05	5.9	3.8
17	2.57	2.60	2.54	1.1	− 1.2
18	4.75	5.19	5.07	9.3	6.8
19	5.50	6.17	6.02	12.2	9.5
20	3.77	3.94	3.86	4.6	2.4
21	4.83	5.64	5.51	16.8	14.2
22	3.88	4.38	4.35	12.9	12.1
23	4.91	5.55	5.42	13.0	10.4
24	4.05	3.81	3.71	− 5.9	− 8.3
25	6.38	7.30	7.13	14.4	11.8
26	4.18	4.53	4.42	8.3	5.7
27	5.57	5.12	5.02	− 8.1	− 9.9
28	2.50	2.72	2.66	8.8	6.4
29	3.43	4.20	4.10	22.4	19.3
30	4.75	4.82	4.70	1.5	− 1.0
31	5.52	6.51	5.67	18.0	2.8
32	4.09	4.46	4.36	9.0	6.6
33	5.02	5.75	5.63	14.5	12.0
34	2.71	2.80	2.73	3.3	0.6
35	3.44	4.09	3.98	18.8	15.7
36	3.81	4.41	4.31	15.8	13.3
37	3.18	3.25	3.18	2.2	− 0.1
38	5.86	6.46	6.32	10.2	7.8
39	6.03	6.57	6.40	9.0	6.1
40	4.84	4.85	4.75	0.2	− 1.9
Mean	4.15	4.45	4.33	7.2	4.4
SD	1.03	1.19	1.14	8.3	8.0
Min	2.07	2.36	2.31	− 9.7	− 12.0
Max	6.38	7.30	7.13	22.4	19.3
RMSD				10.9	9.1