Table 3 Dosimetry workflow in patients using the reference dosimetry approach Dosimetry Toolkit + OLINDA and the new workstation PLANET® Dose

Calibration procedure

SPECT/CT acquisitions

Calibration factor (counts.s⁻¹.MBq⁻¹)

SPECT/CT acquisitions

Calibration factor (Bq.Count⁻¹)

Clinical imaging

4 SPECT/CT at 4 h, 24 h, 72 h and 192 h after injection—60 projections of 45 s

Reconstruction

« Preparation for Dosimetry Toolkit» 6 iterations 10 subsets-AC, SC, RR, Gaussian post filter 0.11 cm

Registration

« Preparation for Dosimetry Toolkit» application

Automatic rigid registration using CT images (Full FOV)

Organ-based rigid registration using CT images

Segmentation and propagation

Manual segmentation using the first CT image

Rigid propagation (constant volumes)

Segmentation adjusted by translation or rotation for other images

Manual segmentation using the first CT image

Rigid propagation (constant volumes)

No adjustment for other images

TIA fitting

Mono-exponential

Mono-exponential 

Absorbed dose calculation

OLINDA/EXM® V1.0

Patient-adapted organ masses

Local Deposition Method (LDM)

Dose Kernel (DK) approach with/without density correction