Table 2 General characteristics for each step of the dosimetry workflow in the currently used dosimetry “Dosimetry Toolkit + OLINDA” software (the reference in this study), and the new PLANET® Dose package
Dosimetry Toolkit® + OLINDA/EXM® V1.0 | PLANET® Dose | |
|---|---|---|
Calibration procedure | GE recommendations: planar acquisitions Calibration factor: counts.s−1.MBq−1 | No manufacturer’s recommendations Calibration factor: Bq.Count−1 |
Clinical imaging expected | Whole body scans, SPECT/CT or hybrid 5 time points maximum Only from GE devices | SPECT/CT or hybrid Unlimited time points Import in DICOM format from all devices |
Reconstruction | « Preparation for Dosimetry Toolkit» application | Non applicable |
Registration | « Preparation for Dosimetry Toolkit» application Automatic rigid registration between CT images (Full FOV) | Rigid or elastic registration Using CT data |
Segmentation and propagation | Manual, semi-automatic or automatic segmentation using the first images (NM or CT) Rigid propagation (constant volumes) Segmentation adjusted by translation or rotation on others CT images | Manual, semi-automatic or automatic segmentation using the first images (NM or CT) Rigid propagation (constant volumes) No adjustment on others CT images |
TIA fitting | Mono-exponential exclusively | Mono-exponential, Bi-exponential, Xexp, Trapezoidal, Tri-exponential, … |
Absorbed dose calculation | Not avalaible on Dosimetry Toolkit® TIAC exported to OLINDA/EXM® V1.0 | Local Deposition Method (LDM) Dose Kernel (DK) approach with / without density correction |
Import/export | Not applicable | DICOM format (DICOM-RT-Structure and RT-Dose) |