TY - JOUR AU - Yang, Dae-Myoung AU - Li, Fiona AU - Bauman, Glenn AU - Chin, Joseph AU - Pautler, Stephen AU - Moussa, Madeleine AU - Rachinsky, Irina AU - Valliant, John AU - Lee, Ting-Yim PY - 2021 DA - 2021/01/04 TI - Kinetic analysis of dominant intraprostatic lesion of prostate cancer using quantitative dynamic [18F]DCFPyL-PET: comparison to [18F]fluorocholine-PET JO - EJNMMI Research SP - 2 VL - 11 IS - 1 AB - Identification of the dominant intraprostatic lesion(s) (DILs) can facilitate diagnosis and treatment by targeting biologically significant intra-prostatic foci. A PSMA ligand, [18F]DCFPyL (2-(3-{1-carboxy-5-[(6-[18F]fluoro-pyridine-3-carbonyl)-amino]-pentyl}-ureido)-pentanedioic acid), is better than choline-based [18F]FCH (fluorocholine) in detecting and localizing DIL because of higher tumour contrast, particularly when imaging is delayed to 1 h post-injection. The goal of this study was to investigate whether the different imaging performance of [18F]FCH and [18F]DCFPyL can be explained by their kinetic behaviour in prostate cancer (PCa) and to evaluate whether DIL can be accurately detected and localized using a short duration dynamic positron emission tomography (PET). SN - 2191-219X UR - https://doi.org/10.1186/s13550-020-00735-w DO - 10.1186/s13550-020-00735-w ID - Yang2021 ER -