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Table 5 Intraobserver agreement. Malignant lesion and healthy tissue reference measurements (ROImax or ratio; mean ± SD) and their ratios, of observer B and C from two timepoints, with intraclass correlation coefficient (ICC), its 95% confidence interval (CI) and descriptive ICC level of agreement

From: Inter- and intraobserver agreement of the quantitative assessment of [99mTc]-labelled anti-programmed death-ligand 1 (PD-L1) SPECT/CT in non-small cell lung cancer

SPECT Observer B Observer C
1 2 ICC (95% CI) ICC level of agreement 1 2 ICC (95% CI) ICC level of agreement
ROImax (mean ± SD) ROImax (mean ± SD) ROImax (mean ± SD) ROImax (mean ± SD)
Malignant lesion(s) ROI
 Primary lung tumour (T) 560 ± 154 552 ± 146 0.96 (0.93–0.98) Excellent 568 ± 157 560 ± 156 0.95 (0.91–0.97) Excellent
 Lymph node metastasis (LN) 461 ± 167 454 ± 177 0.97 (0.94–0.98) Excellent 448 ± 163 460 ± 166 0.97 (0.95–0.98) Excellent
Healthy reference tissue
 Blood pool (BP) 295 ± 80 289 ± 82 0.98 (0.96–0.99) Excellent 270 ± 83 272 ± 83 0.97 (0.94–0.98) Excellent
 Lung (freehand) 310 ± 157 321 ± 121 0.87 (0.77–0.92) Good to excellent 251 ± 88 246 ± 97 0.91 (0.84–0.95) Good to excellent
 Lung (AA) 279 ± 108 266 ± 112 0.94 (0.89–0.97) Good to excellent 250 ± 94 258 ± 105 0.94 (0.88–0.96) Good to excellent
 Lung (C) 286 ± 129 291 ± 127 0.94 (0.9–0.97) Good to excellent 289 ± 128 302 ± 121 0.96 (0.92–0.98) Excellent
 Liver (freehand) 1262 ± 288 1288 ± 308 0.98 (0.95–0.99) Excellent 1194 ± 274 1192 ± 269 0.99 (0.99–1.00) Excellent
 Liver (GOJ) 1185 ± 270 1176 ± 257 0.97 (0.94–0.98) Excellent 1219 ± 283 1223 ± 283 0.98 (0.97–0.99) Excellent
  ROImax ratio (mean ± SD) ROImax ratio (mean ± SD) ICC (95% CI) ICC level of agreement ROImax ratio (mean ± SD) ROImax ratio (mean ± SD) ICC (95% CI) ICC level of agreement
Ratios
 T:BP 1.99 ± 0.67 2.01 ± 0.65 0.96 (0.92–0.98) Excellent 2.20 ± 0.77 2.17 ± 0.81 0.95 (0.90–0.97) Good to excellent
 T:L (freehand) 2.01 ± 0.71 1.86 ± 0.66 0.84 (0.69–0.92) Moderate to excellent 2.40 ± 0.86 2.42 ± 0.87 0.92 (0.85–0.96) Good to excellent
 T:L (AA) 2.17 ± 0.86 2.24 ± 0.70 0.84 (0.72–0.91) Moderate to excellent 2.41 ± 0.90 2.32 ± 0.85 0.91 (0.83–0.95) Good to excellent
 T:L (C) 2.20 ± 0.92 2.08 ± 0.72 0.85 (0.74–0.92) Moderate to excellent 2.18 ± 0.88 1.99 ± 0.68 0.87 (0.71–0.94) Moderate to excellent
 LN:BP 1.65 ± 0.51 1.64 ± 0.58 0.95 (0.91–0.97) Excellent 1.76 ± 0.66 1.77 ± 0.60 0.95 (0.91–0.97) Excellent
  1. AA aortic arch, BP blood pool, C carina, CI confidence interval, ICC intraclass correlation coefficient, GOJ gastroesophageal junction, L lung, LN lymph node metastasis, ROI region of interest, T primary lung tumour