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Table 5 Intraobserver agreement. Malignant lesion and healthy tissue reference measurements (ROImax or ratio; mean ± SD) and their ratios, of observer B and C from two timepoints, with intraclass correlation coefficient (ICC), its 95% confidence interval (CI) and descriptive ICC level of agreement

From: RETRACTED ARTICLE: Inter- and intraobserver agreement of the quantitative assessment of [99mTc]-labelled anti-programmed death-ligand 1 (PD-L1) SPECT/CT in non-small cell lung cancer

SPECT

Observer B

Observer C

1

2

ICC (95% CI)

ICC level of agreement

1

2

ICC (95% CI)

ICC level of agreement

ROImax (mean ± SD)

ROImax (mean ± SD)

ROImax (mean ± SD)

ROImax (mean ± SD)

Malignant lesion(s) ROI

 Primary lung tumour (T)

560 ± 154

552 ± 146

0.96 (0.93–0.98)

Excellent

568 ± 157

560 ± 156

0.95 (0.91–0.97)

Excellent

 Lymph node metastasis (LN)

461 ± 167

454 ± 177

0.97 (0.94–0.98)

Excellent

448 ± 163

460 ± 166

0.97 (0.95–0.98)

Excellent

Healthy reference tissue

 Blood pool (BP)

295 ± 80

289 ± 82

0.98 (0.96–0.99)

Excellent

270 ± 83

272 ± 83

0.97 (0.94–0.98)

Excellent

 Lung (freehand)

310 ± 157

321 ± 121

0.87 (0.77–0.92)

Good to excellent

251 ± 88

246 ± 97

0.91 (0.84–0.95)

Good to excellent

 Lung (AA)

279 ± 108

266 ± 112

0.94 (0.89–0.97)

Good to excellent

250 ± 94

258 ± 105

0.94 (0.88–0.96)

Good to excellent

 Lung (C)

286 ± 129

291 ± 127

0.94 (0.9–0.97)

Good to excellent

289 ± 128

302 ± 121

0.96 (0.92–0.98)

Excellent

 Liver (freehand)

1262 ± 288

1288 ± 308

0.98 (0.95–0.99)

Excellent

1194 ± 274

1192 ± 269

0.99 (0.99–1.00)

Excellent

 Liver (GOJ)

1185 ± 270

1176 ± 257

0.97 (0.94–0.98)

Excellent

1219 ± 283

1223 ± 283

0.98 (0.97–0.99)

Excellent

 

ROImax ratio (mean ± SD)

ROImax ratio (mean ± SD)

ICC (95% CI)

ICC level of agreement

ROImax ratio (mean ± SD)

ROImax ratio (mean ± SD)

ICC (95% CI)

ICC level of agreement

Ratios

 T:BP

1.99 ± 0.67

2.01 ± 0.65

0.96 (0.92–0.98)

Excellent

2.20 ± 0.77

2.17 ± 0.81

0.95 (0.90–0.97)

Good to excellent

 T:L (freehand)

2.01 ± 0.71

1.86 ± 0.66

0.84 (0.69–0.92)

Moderate to excellent

2.40 ± 0.86

2.42 ± 0.87

0.92 (0.85–0.96)

Good to excellent

 T:L (AA)

2.17 ± 0.86

2.24 ± 0.70

0.84 (0.72–0.91)

Moderate to excellent

2.41 ± 0.90

2.32 ± 0.85

0.91 (0.83–0.95)

Good to excellent

 T:L (C)

2.20 ± 0.92

2.08 ± 0.72

0.85 (0.74–0.92)

Moderate to excellent

2.18 ± 0.88

1.99 ± 0.68

0.87 (0.71–0.94)

Moderate to excellent

 LN:BP

1.65 ± 0.51

1.64 ± 0.58

0.95 (0.91–0.97)

Excellent

1.76 ± 0.66

1.77 ± 0.60

0.95 (0.91–0.97)

Excellent

  1. AA aortic arch, BP blood pool, C carina, CI confidence interval, ICC intraclass correlation coefficient, GOJ gastroesophageal junction, L lung, LN lymph node metastasis, ROI region of interest, T primary lung tumour