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Table 1 Patient characteristics in three quantiled TMB groups (N = 273 patients)

From: Relationship between tumor mutational burden and maximum standardized uptake value in 2-[18F]FDG PET (positron emission tomography) scan in cancer patients

  TMB (0–1 mutations/mb)
N = 39
TMB (2–11 mutations/mb)
N = 174
TMB (≥ 12 mutations/mb)
N = 60
p value
TMB (Mean ± SD) 0 5.2 ± 2.5 37.4 ± 47.6 Not applicable
Median 0 5 20  
SUVmax (Mean ± SD) 4.5 ± 3.9 8.4 ± 7.8 11.2 ± 8.5 p < 0.0001
Median (range) 3.9 (0–16.4) 6.8 (0–74.0) 9.2 (1.6–49.6)  
Age at time of biopsy (years) (Mean ± SD) 68.5 ± 12.5 63.9 ± 13.7 68.3 ± 12.8 p = 0.03
Median (range) 71 (34–91) 65 (23–96) 70 (28–89)  
Women (N (%)) 22 (14%) 104 (67%) 30 (19%) p = 0.4
Men (N (%)) 17 (14%) 70 (60%) 30 (26%)  
Melanoma (N = 15) 2 (13%) 4 (27%) 9 (60%) p < 0.001
Lung cancer (N = 61) 5 (8%) 38 (62%) 18 (30%)
Gastrointestinal (N = 36) 3 (9%) 29 (80%) 4 (11%)
Breast (N = 43) 7 (16%) 33 (77%) 3 (7%)
Other (N = 118)* 22 (19%) 70 (59%) 26 (22%)
  1. SD standard deviation, SUV standardized uptake value, TMB tumor mutational burden
  2. *Other cancers consisted of head and neck, adrenal, bladder, ovary, uterus, prostate, musculoskeletal, and hematologic malignancies, and cancers of unknown primary