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Table 1 Patient characteristics in three quantiled TMB groups (N = 273 patients)

From: Relationship between tumor mutational burden and maximum standardized uptake value in 2-[18F]FDG PET (positron emission tomography) scan in cancer patients

 

TMB (0–1 mutations/mb)

N = 39

TMB (2–11 mutations/mb)

N = 174

TMB (≥ 12 mutations/mb)

N = 60

p value

TMB (Mean ± SD)

0

5.2 ± 2.5

37.4 ± 47.6

Not applicable

Median

0

5

20

 

SUVmax (Mean ± SD)

4.5 ± 3.9

8.4 ± 7.8

11.2 ± 8.5

p < 0.0001

Median (range)

3.9 (0–16.4)

6.8 (0–74.0)

9.2 (1.6–49.6)

 

Age at time of biopsy (years) (Mean ± SD)

68.5 ± 12.5

63.9 ± 13.7

68.3 ± 12.8

p = 0.03

Median (range)

71 (34–91)

65 (23–96)

70 (28–89)

 

Women (N (%))

22 (14%)

104 (67%)

30 (19%)

p = 0.4

Men (N (%))

17 (14%)

70 (60%)

30 (26%)

 

Melanoma (N = 15)

2 (13%)

4 (27%)

9 (60%)

p < 0.001

Lung cancer (N = 61)

5 (8%)

38 (62%)

18 (30%)

Gastrointestinal (N = 36)

3 (9%)

29 (80%)

4 (11%)

Breast (N = 43)

7 (16%)

33 (77%)

3 (7%)

Other (N = 118)*

22 (19%)

70 (59%)

26 (22%)

  1. SD standard deviation, SUV standardized uptake value, TMB tumor mutational burden
  2. *Other cancers consisted of head and neck, adrenal, bladder, ovary, uterus, prostate, musculoskeletal, and hematologic malignancies, and cancers of unknown primary