EJNMMI Research

Table 1 Model parameters for test (S1) and retest (S2) scans for grey matter and selected regions of interest (ROIs)

From: Evaluation of [ ¹³ N]ammonia positron emission tomography as a potential method for quantifying glutamine synthetase activity in the human brain

ROI	[¹⁵O]water [n = 8]		[¹³N]ammonia [n = 5]
ROI	CBF (mL/100 g/min)		K₁ (mL/100 g/min)		k₂ (1/min)		k₃ (1/min)
	S1	S2	S1	S2	S1	S2	S1	S2
Grey Matter	37.6 ± 4.8	38.5 ± 3.4	20.1 ± 1.5	18.7 ± 1.3	0.0072 ± 0.0035	0.0096 ± 0.0042	0.0031 ± 0.0045	0.0177 ± 0.0259
White Matter	25.8 ± 3.4	26.4 ± 2.7	14.6 ± 1.1	13.7 ± 0.7	0.0073 ± 0.0043	0.0096 ± 0.0053	0.0139 ± 0.0177	0.0274 ± 0.0401
Hippocampus_l	32.1 ± 3.7	33.8 ± 3.1	19.7 ± 2.8	18.8 ± 1.6	0.0256 ± 0.0145	0.0360 ± 0.0212	0.0532 ± 0.0261	0.0621 ± 0.0304
OL_ling_G_l	40.8 ± 5.4	41.5 ± 2.8	23.7 ± 3.0	21.6 ± 0.9	0.0072 ± 0.0023	0.0090 ± 0.0035	0.0000 ± 0.0000	0.0125 ± 0.0172
G_cing_post_l	43.6 ± 5.3	44.3 ± 4.2	22.2 ± 1.6	20.8 ± 1.3	0.0069 ± 0.0038	0.0099 ± 0.0059	0.0038 ± 0.0052	0.0154 ± 0.0231
Putamen_l	45.3 ± 7.3	46.1 ± 5.5	23.3 ± 1.9	21.2 ± 1.5	0.0063 ± 0.0028	0.0086 ± 0.0037	0.0000 ± 0.0000	0.0144 ± 0.0203
Thalamus_l	43.9 ± 5.5	44.5 ± 4.2	22.8 ± 2.4	21.2 ± 1.2	0.0128 ± 0.0057	0.0178 ± 0.0075	0.0241 ± 0.0214	0.0405 ± 0.0234
Cerebellum_l	41.7 ± 6.8	42.6 ± 5.2	22.5 ± 2.0	20.7 ± 1.3	0.0070 ± 0.0047	0.0088 ± 0.0034	0.0056 ± 0.0126	0.0145 ± 0.0216

The table presents estimates of cerebral blood flow (CBF) from [¹⁵O]water scans, and irreversible two tissue compartmental model parameter estimates for rate constants K₁, k₂ and k₃ from [¹³N]ammonia scans. Data are presented as mean ± standard deviation for grey matter, white matter and the left (l) hippocampus, lingual gyrus (OL_ling_G), posterior cingulate gyrus (G_cing_post), putamen, thalamus, and cerebellum

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