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EJNMMI Research
Fig. 2 | EJNMMI Research

Fig. 2

From: Sapap3 deletion causes dynamic synaptic density abnormalities: a longitudinal [11C]UCB-J PET study in a model of obsessive–compulsive disorder-like behaviour

Fig. 2

a The averaged [11C]UCB-J PET VT(IDIF) maps superimposed on a mouse MR template at 3 and 9 mo for both genotypes, b combined with the corresponding averaged [11C]UCB-J PET VT(IDIF) values ± SD. Young adult Sapap3 ko mice are characterized by a lower synaptic density availability in the cortex, the striatum, the thalamus, and the hippocampus when compared to their wt counterparts. Also, both genotypes show a progressive decline in synaptic density availability with ageing, which was more pronounced in the wt controls. The corresponding averaged values ± SD can be consulted in Additional file 1: Table 1. (ko, knockout; mo, months; MR, magnetic resonance; wt, wildtype; VT(IDIF), volume-of-distribution; *p < 0.05, **p < 0.01, ***p < 0.001)

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