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Fig. 4 | EJNMMI Research

Fig. 4

From: Blocking of efflux transporters in rats improves translational validation of brain radioligands

Fig. 4

PET images, AUC and SBR values for the D2/3 receptor tracer [18F]Fallypride. Representative horizontal rat PET images, 60-min AUC values (min × g/mL) and SBR values are shown for baseline, target block with haloperidol, P-gp inhibition with elacridar and combined P-gp inhibition—target block conditions (see Table 1 for details on drug dosing and PET image summation, n = 2). Str striatum, Cb cerebellum, Wb whole brain, AUC area under the curve, SBR specific binding ratios, P-gp P-glycoprotein

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