Fig. 4

PET images, AUC and SBR values for the D_2/3 receptor tracer [¹⁸F]Fallypride. Representative horizontal rat PET images, 60-min AUC values (min × g/mL) and SBR values are shown for baseline, target block with haloperidol, P-gp inhibition with elacridar and combined P-gp inhibition—target block conditions (see Table 1 for details on drug dosing and PET image summation, n = 2). Str striatum, Cb cerebellum, Wb whole brain, AUC area under the curve, SBR specific binding ratios, P-gp P-glycoprotein