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Fig. 3 | EJNMMI Research

Fig. 3

From: Blocking of efflux transporters in rats improves translational validation of brain radioligands

Fig. 3

PET images (a), AUC and SBR values (b) for the 5-HT7 receptor tracers [11C]Cimbi-717, [11C]Cimbi-701, and [11C]BA-10. Representative horizontal rat PET images, 60-min AUC values (min × g/mL) and SBR values are shown for baseline, target block with SB-269970, P-gp inhibition with elacridar and combined P-gp inhibition—target block conditions (see Table 1 for details on drug dosing and PET image summation). Numbers of rats scanned per experimental condition are shown in Additional file 1: Table S2. Wb whole brain, Tha thalamus, Cb cerebellum, AUC area under the curve, SBR specific binding ratios, P-gp P-glycoprotein

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