Fig. 2
From: Blocking of efflux transporters in rats improves translational validation of brain radioligands
PET images (a), AUC and SBR values (b) for the 5-HT2A receptor tracers [18F]MH.MZ, [18F]Altanserin, [11C]Pimavanserin and [11C]Cimbi-36. Representative horizontal rat PET images, 60-min AUC values (min × g/mL) and SBR values are shown for baseline, target block with ketanserin, efflux transporter inhibition and combined P-gp inhibition—target block conditions (see Table 1 for details on drug dosing and PET image summation). n.d. = summed PET image could not be generated. Numbers of rats scanned per experimental condition are shown in Additional file 1: Table S2. Wb whole brain, mPFC medial prefrontal cortex, FC frontal cortex, AUC area under the curve, SBR specific binding ratios, P-gp P-glycoprotein