Fig. 1From: Blocking of efflux transporters in rats improves translational validation of brain radioligandsTracer evaluation strategy. Step 1 and 2: Traditionally, specific binding can be determined by comparing tracer uptake at baseline and after target block (Case A). This work proposes to perform the same two experiments with simultaneous inhibition of P-gp (Case B). Step 3: If specific binding is observed in Case A or B, a successful translation from rodent to pig is predictedBack to article page