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Fig. 1 | EJNMMI Research

Fig. 1

From: Blocking of efflux transporters in rats improves translational validation of brain radioligands

Fig. 1

Tracer evaluation strategy. Step 1 and 2: Traditionally, specific binding can be determined by comparing tracer uptake at baseline and after target block (Case A). This work proposes to perform the same two experiments with simultaneous inhibition of P-gp (Case B). Step 3: If specific binding is observed in Case A or B, a successful translation from rodent to pig is predicted

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