Table 3 Multivariate stepwise regression between twelve PET parameters (SUVmax, SUVmean, TMTV, TLG, TMTS, TVSR, TumBB, Dmax, nROI, itErosion, medPCD, medEdgeD) and two blood DNA parameters ([cfDNA], [ctDNA]) with adjusted R-squared (R²) and p values

(Intercept) − 7.78e03

 + TMTV*20.1

 + itErosion*2.25e04

 + medEdgeD* − 7.33e02

(Intercept) 1.89e04

 + TMTV* − 6.14e01

 + TMTS*5.25e01

 + TVSR*1.05e04

 + TumBB* − 5.28e−01

 + Dmax*6.04e01

 + nROI* − 1.05e03

 + itErosion* − 4.18e04

(Intercept) − 7.72e03

 + itErosion*9.95e03

 + TMTS*5.06

 + medEdgeD* − 2.86e02

(Intercept) 3.62e02

 + TMTS*7.82e − 01

 + TVSR*2.09e02

 + TumBB* − 2.55e−02

 + Dmax*2.72e00

 + nROI* − 4.41e01

 + medPCD*4.31e01

 + medEdgeD* − 9.28e01

[R² = 0.53] (p < 0.001)

[R² = 0.28] (p = 0.006)

[R² = 0.44] (p = 0.002)

[R² = 0.40] (p = 0.005)