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Table 1 Patients characteristics and values of PET and blood DNA parameters

From: Correlations between baseline 18F-FDG PET tumour parameters and circulating DNA in diffuse large B cell lymphoma and Hodgkin lymphoma

  DLBCL
(n = 27)
n (%)
cHL
(n = 48)
n (%)
Median age [range] (in years) 69 [20–93] 33 [20–86]
Male 15 (55.5%) 22 (45.8%)
Stage III/IV (vs. I/II) 20 (74%) 20 (41.7%)
LDH > ULN 10 (37%) 8 (17%, NA = 1)
Spleen involvement 2 (7%) 3 (6%)
Median time interval between blood sample and PET [maximal] (in days) 9 [61] 8 [65]
  PET parameters
mean (± SD) [min–max]
 
(1) SUVmax 22.4 (± 8.3) [4.3–35.5] 15.4 (± 6.2) [3.6–33.8]
(2) SUVmean 10.3 (± 3.6) [2.9–17.3] 5.7 (± 1.8) [2.2–11.3]
(3) TMTV (cm3) 761 (± 898) [0.2–2927] 280 (± 291) [2–1256]
(4) TLG 8596 (± 10,068) [0.7–30,773] 1537(± 1444) [5–6520]
(5) TMTS (cm2) 910 (± 1017) [2–3309] 570 (± 570) [12–3218]
(6) TVSR (mm) 7.0 (± 3.4) [1.2–15.2] 4.5 (± 1.6) [1.9–9.6]
(7) TumBB (cm3) 13,997 (± 18,021) [0–60,982] 12,961 (± 22,462) [6–107,039]
(8) Dmax (mm) 404 (± 294) [10–1026] 376 (± 313) [26–1175]
(9) nROI 9.2 (± 12.6) [1–65] 12 (± 10.8) [1–49]
(10) itErosion 2.2 (0.8) [1–4.46] 1.6 (± 0.4) [1.0–2.8]
(11) medPCD (mm) 49.8 (± 29.7) [3.9–117.5] 29.6 (± 15.1) [7.7–80.1]
(12) medEdgeD (mm) 44.6 (± 20.2) [3.3–79.4] 29.2 (± 10.2) [11.3–57.6]
  Blood cell-free DNA parameters
mean (± SD) [min–max]
 
[cfDNA] (hGE/mL) 22,665 (± 28,414)[4206–124,425] 13,771 (± 18,975)[2023–88,046]
[ctDNA] (hGE/mL) 4961 (± 9948) [2–39,151]
(3 NA, no mutation found)
335 (± 623)[10–2684]
(15 NA, no mutation found)
  1. cfDNA circulating free DNA, cHL classical Hodgkin's lymphoma, ctDNA circulating tumour DNA, DLBCL diffuse large B cell lymphoma, LDH lactate dehydrogenase, NA not available, PET positron emission tomography