Skip to main content

Table 3 Pharmacokinetic parameters of 18F-deoxy-thiamine in ICR mice (n = 5)

From: A novel PET tracer 18F-deoxy-thiamine: synthesis, metabolic kinetics, and evaluation on cerebral thiamine metabolism status

Parameters (units)

Values

Tmax (s)

0–10

Cmax (IA%/g)

18.12 ± 2.20a

VD1 (g)

3.058

CL1 (g/min)

2.674

VD2 (g)

19.308

CL2 (g/min)

20.162

t1/2(α) (min)

0.082

t1/2(β) (min)

6.379

AUC0–60 min (%IA/g * min)

37.313

AUC0–inf (%IA/g * min)

37.399

k10 (min−1)b

0.874

k12 (min−1)b

6.593

k21 (min−1)b

1.044

  1. aData were expressed as mean ± SEM
  2. bK10, elimination rate constant; K12, elimination rate constant from central compartment to peripheral compartment; K21, elimination rate constant from peripheral compartment to central compartment