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Fig. 6 | EJNMMI Research

Fig. 6

From: A novel PET tracer 18F-deoxy-thiamine: synthesis, metabolic kinetics, and evaluation on cerebral thiamine metabolism status

Fig. 6

The representative results of in vivo stability study on 18F-deoxy-thiamine. a, b HPLC results for the mixture of mouse urine extracts and cold standard sample of 18F-deoxy-thiamine. a The radio-signal, and the retention time of 18F-deoxy-thiamine was 9 min 54 s. Note that the unknown metabolite(s) was ahead of 18F-deoxy-thiamine (arrow). b The UV-signal, and the retention time of cold standard sample was 9 min 14 s (arrowhead). The UV-signal acquisition system was ahead of radio-signal, and the time-lag was about half-minute. c The UV signal of analyzing only the mouse urine extracts. UV = 254 nm. The peak around 3 min in b, c was the metabolic compounds excreted through kidney into urine. Although the urine was treated by deproteinization, centrifugation, and filtration, many in-vivo metabolic compounds could not be separated and removed

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