Fig. 3

The evaluation of cerebral thiamine metabolism status in mice and marmosets. a, b C57BL/6 mice. A: the cerebral TACs of ¹⁸F-deoxy-thiamine in 90 min. The average AUC value in two mice with TD was 1.9 times higher than that in control mice (38.73 ± 3.74 vs. 20.38 ± 3.23). b The representative PET/CT images in TD and control groups (TD 5 and Ctrl 2, both at 50–60 min). c, d ICR mice. c The cerebral TACs of ¹⁸F-deoxy-thiamine in 90 min. The AUC values in mice with TD were significantly higher than those in controls (68.28 ± 10.74 vs. 21.88 ± 4.25, P = 0.016). d The representative PET/CT images in TD and control mice (TD 4 and Ctrl 1, 50–60 min). e, j Marmosets. e The cerebral TACs of ¹⁸F-deoxy-thiamine in 60 min. f The representative PET/CT images (M4, 30–60 min). g–i The correlations between cerebral AUC values of ¹⁸F-deoxy-thiamine within 60 min and blood levels of thiamine, TMP, and TDP. j The correlation between cerebral transfer constant K_i and age