KRAS mutation effects on the 2-[18F]FDG PET uptake of colorectal adenocarcinoma metastases in the liver

EJNMMI Research

Table 4 Statistics for the separation of KRAS missense mutations based on 2-[18F]FDG uptake when KRAS gene amplification is grouped with wild type for all 60 lesions in 39 interventional PET/CT scans

Parameter	Mean		Peak		Max		Statistic
Parameter	MIM	HERMES	MIM	HERMES	MIM	HERMES	Statistic
SUV No corr	0.05	0.02	0.07	0.04	0.01	0.01 0.01 0.692	Stud. t test Wilc. R. Sum AUC
SUV PVE corr	0.03	0.01	0.03	0.02	0.004	0.006 0.005 0.715	Stud. t test Wilc. R. Sum AUC
SUVTLR PVE corr	0.02	0.02	0.02	0.02	0.006	0.009 0.004 0.722	Stud. t test Wilc. R. Sum AUC
SUV PVE + time corr	0.03	0.01	0.03	0.02	0.005	0.006 0.005 0.714	Stud. t test Wilc. R. Sum AUC
SUR time corr	0.004	0.002	0.02	0.01	0.003	0.003 0.002 0.733	Stud. t test Wilc. R. Sum AUC
SUR PVE + time corr	0.002 0.003 0.725	0.0009 0.0004 0.770	0.004 0.004 0.723	0.003 0.002 0.738	0.0005 0.0005 0.766	0.0008 0.001 0.753	Stud. t test Wilc. R. Sum AUC

Student’s t test p values are given for all metrics, while Wilcoxon rank sum test with continuity correction p values (abbreviated to Wilc. R. Sum) and AUC are given as a second and third line number only for PVE- and time-corrected SUR (bottom row) and for the maximum values derived from the Hermes segmentation contours. Values obtained after PVE and uptake time correction as well as for derivative metrics as tumor-to-liver ratio (SUVTLR) and tumor-to-blood ratio (SUR) are provided