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Table 1 αvβ8-Integrin affinities (expressed as 50% inhibition concentrations, IC50) and n-octanol-PBS distribution coefficients (log D7.4). Affinities were determined using the non-radioactive 69/71GaIII complexes, where applicable

From: Tracking a TGF-β activator in vivo: sensitive PET imaging of αvβ8-integrin with the Ga-68-labeled cyclic RGD octapeptide trimer Ga-68-Triveoctin

Compound

IC50 (95% confidence interval) [nm]

log D7.4

68Ga-Triveoctin (trimer)

5.7 (3.6–9.0)

− 3.1 ± 0.1

68Ga-TRAP-AvB8 (monomer)

38 (25–58)

− 3.9 ± 0.1

AvB8-pentynoic amide

17 (12–24)

n/a