Plasma radio-metabolite analysis of PET tracers for dynamic PET imaging: TLC and autoradiography

EJNMMI Research

Table 3 Median differences in parameters estimated from simulation study

Parameter	K₁ (mL min⁻¹ g⁻¹)	k₂ (min⁻¹)	k₃ (min⁻¹)	k₄ (min⁻¹)	V_p (ml g⁻¹)	DV (ml g⁻¹)	W (min)
Median difference	0.003	− 0.124	0.111	− 0.052	0.004	0.806	0.021
P	0.75	0.004	0.005	0.004	0.013	0.004	0.083
Bias (%)^a	198.3	− 32.7	115.4	− 390.3	109.2	81.2	181.0

Median differences between parameters in Table 1 estimated using AIF with and without metabolite correction. P value is estimated by nonparametric paired test
^aAlthough the differences in the estimated parameters were not normally distributed, the percentage bias was used to approximate the expected error