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Table 3 Kinetic parameters, determined using compartment analysis

From: Quantitative evaluation of hepatic integrin αvβ3 expression by positron emission tomography imaging using 18F-FPP-RGD2 in rats with non-alcoholic steatohepatitis

Group

Model

K1

k2

k3

k4

AIC

3–4 weeks

Normal diet

1T2CM

1.06 ± 0.26

2.08 ± 0.40

89.33 ± 4.8

2T3CM

1.43 ± 0.34

3.63 ± 0.87

0.05 ± 0.012

0.03 ± 0.0063

35.96 ± 3.8

CDHFD

1T2CM

0.74 ± 0.14

1.15 ± 0.32

93.31 ± 10.7

2T3CM

0.90 ± 0.12

1.94 ± 0.47

0.05 ± 0.020

0.02 ± 0.0021

41.14 ± 3.9

9–10 weeks

Normal diet

1T2CM

0.87 ± 0.34

1.56 ± 0.85

97.59 ± 3.8

2T3CM

1.26 ± 0.14

3.00 ± 0.40

0.05 ± 0.0075

0.02 ± 0.0048

43.93 ± 5.9

CDHFD

1T2CM

0.42 ± 0.26

0.51 ± 0.61

100.3 ± 7.9

2T3CM

0.69 ± 0.14

1.19 ± 0.39

0.07 ± 0.0079

0.02 ± 0.0029

32.12 ± 7.8

  1. Values are expressed as means ± SDs (n = 5)
  2. CDHFD choline-deficient, low-methionine high-fat diet, 1T2CM one-tissue two-compartment model, 2T3CM two-tissue three-compartment model, AIC Akaike information criterion